• Pathology-Anatomic
• Pathology-Neuropathology

• Director, Neuropathology and Neuropathology Research
• Member of the Neuroscience Program, and The Miami Project to Cure Paralysis (Affiliate Faculty)
• Professor, Department of Pathology, Biochemistry & Molecular Biology, Neurology, Neurosurgery

Metabolic encephalopathies, neurotrauma, and neurodegenerative disorders.

Normal function and properties of glia; neurotransmitter transport in glia; role of glia and steroids in neuroprotection; mechanisms and significance of reactive gliosis; role of glia in various neurological conditions (trauma, aging/Alzheimer's disease, Parkinson's disease, brain edema, liver failure); the role of oxidative stress and the mitochondrial permeability transition in CNS trauma and liver failure. Additionally, we are investigating the cellular and molecular events associated with human spinal cord injury. Our studies utilize animal models of human disease and the use of cell culture (astrocytes, microglia, neurons, endothelial cells). Techniques employed in our laboratory include morphology (including immunohistochemistry, confocal microscopy, in situ hybridization, electron microscopy), molecular biology, analysis of membrane receptors, calcium imaging and various biochemical / pharmacological methods.