Sylvester Comprehensive Cancer Center

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Adam Wanner, M.D.

General Information

Adam  Wanner, M.D.

Languages

  • English
  • German
  • Spanish
  • French
  • Hungarian

Certifications

  • American Board of Internal Medicine
  • American Board of Internal Med-Pulmonary Disease

CV

Specialties

  • Pulmonary Disease - Internal Medicine
  • Internal Medicine

Roles

  • Joseph Weintraub Professor of Medicine, Pediatrics and Biomedical Engineering
  • Professor of Medicine
  • Scientific Director Alpha-1 Foundation

Clinical Interests

Pulmonary Medicine, Asthma and COPD

Research Interests

 See bio

Awards

Education

1972 Pulmonary Fellowship
Mount Sinai Medical Center MB
1968 Residency
Jefferson Medical; College
1966 MD
University of Basel
Graduate
University of Basel School of Medicine
Residency
Kantonsspital, Switzerland; Philadelphia General Hospital
Fellowship
Mount Sinai Medical Center

Publications

  • See bio (personal)

Biography

 

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person.  DO NOT EXCEED FOUR PAGES.

 

NAME

Wanner, Adam

POSITION TITLE

Joseph Weintraub Professor of Medicine

eRA COMMONS USER NAME (credential, e.g., agency login)

AWANNER

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

MM/YY

FIELD OF STUDY

University of Basel, Switzerland

M.D.

06/1966

Medicine

 

 

 

 

 

 

 

 

         

B. Positions and Honors

Positions and Employment

1966-1967                   Assistant Thurgauische Heilstaette, Davos, Switzerland

1967-1968                   Medical Internship, Philadelphia General Hospital (Jefferson Medical College)

1968-1970                   Medical Residency, Kantonsspital Aarau, Switzerland 

1970-1972                   Pulmonary Fellowship, Mount Sinai Medical Center, Miami Beach

1972                            ABIM Internal Medicine

1974                            ABIM Pulmonary Medicine

1972-1975                   Associate, Pulmonary Division, Mount Sinai Medical Center, Miami Beach

1974-present              Assistant/Associate/Full Professor of Medicine, University of Miami

1983-present              Professor of Biomedical Engeneering, University of Miami

1994-present              Professor of Pediatrics, University of Miami

1983-2005                   Chief, Division of Pulmonary/CC, University of Miami

1998-2006                  Vice Chair for Research, Department of Medicine, University of Miami

 

Other Experience and Professional Memberships

1983-1985                 President, Florida Thoracic Society.

1984-1988                 NIH Study Section: Clinical Sciences II. (Chairman, 1987-88).

1984-1988                 VA Merit Review Board (Respiration) (Chairman, 1986-88).

1987-1993                 Governor (Florida), American College of Chest Physici­ans.

1993-present             United Nations Environment Programme (UNEP)

2002-present          Swiss Academy of Medical Sciences (since 2002)

 

2001-2002                   American Thoracic Society President

2004-present              Chairman, NHLBI-CCRN DSMB

2006-present            Scientific Director, Alpha-1 Foundation

Editorial boards:

1980-1985                  American Review of Respiratory Disease

1980-1999                  Journal of Applied Physiology

1984-present             Respiration

1984-1993                  Pediatric Pulmonology

1987-1992                  Pulmonary Pharmacology

1988-present             Lung

1993-present            Journal of Aerosol Medicine

 

1998-2006                   American Journal of Respiratory and Critical Care Medicine

2004-present             Deputy Editor, Proceedings of the American Thoracic Society

 

 

 

Honors

1968                     Best Intern of the Year - Philadelphia General Hospital, Philadelphia, PA.

1974                      Elected Fellow of the American College of Chest Physicians

1976                      Elected Fellow of the American College of Physicians

2003                      Distinguished Faculty Scholar Award - University of Miami, Miami, FL.

2010                     Distinguished Scientist Award, Hungarian Respiratory Society

2010                    John Butler Lifetime Achievement Award (University of Washington).

 

C. Selected Peer-reviewed Publications (from 257 peer-reviewed publications)

-         Zschauer AOA, Sielczak MW, Wanner A.  Norepinephrine-induced contraction of isolated rabbit           bronchial artery: role of α1- and α2-adrenoceptor activation.  J Appl Physiol 1997; 82:1918-1925.  

-           Kumar SD, Emery MJ, Atkins ND, Danta I, Wanner A.  Airway mucosal blood flow in bronchial            asthma.  Am J Respir Crit Care Med 1998; 158:153-156.  

-           Zschauer AOA, Sielczak MW, Wanner A.  Altered contractile sensitivity of isolated bronchial artery to             phenylephrine in ovalbumin sensitized rabbits.  J Appl Physiol 1999; 86:1721-1727.

-           Brieva JL, Danta I, Wanner A.  Effect of an inhaled glucocorticosteroid on airway mucosal blood flow              in mild asthma.  Am J Respir Crit Care Med 2000; 161:293-296. 

-           Kumar SD, Brieva JL, Danta I, Wanner A.  Transient effect of inhaled fluticasone on airway mucosal            blood flow in normals and asthmatics.  Am J Respir Crit Care Med 2000; 161:918-921.

-           Brieva JL, Wanner A.  Adrenergic airway and airway vascular smooth muscle responsiveness in            healthy and asthmatic subjects.  J Appl Physiol 2001; 90:665-669.

 

-          Horvath G, Lieb T, Conner GE, Salathé M, Wanner A.  Steroid sensitivity of norepinephrine uptake by human bronchial arterial and rabbit aortic smooth muscle cells.  Am J Respir Cell Mol Biol 2001; 25(4):500-506. 

-          Horvath G, Torbati A, Conner GE, Salathe M, Wanner A.  Systemic ovalbumin sensitization downregulates norepinephrine uptake by rabbit aortic smooth muscle cells.  Am J Respir Cell Mol Biol 2002; 27:747-751. 

-          Mendes ES, Pereira A, Danta I, Duncan RC, Wanner A.  Comparative bronchial vasoconstrictive  efficacy of inhaled glucocorticosteroids.  Eur Respir J 2003; 21:989-993.

-          Horvath G, Sutto Z, Torbati A, Conner GE, Salathe M, Wanner A.  Norepinephrine transport by the            extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells.  Am J            Physiol Lung Cell Mol Physiol 2003; 285:L829-L837.   

-         Pereira A, Mendes E, Ferreira T, Wanner A.  Effect of inhaled racemic and (R)-albuterol on airway            smooth muscle in healthy and asthmatic subjects.  Lung 2003; 181(4):201-211.   

-          Wanner A, Kumar SD, Brieva JL, Mendes ES.  Adrenergic-glucocorticoid interactions in the             regulation of airway blood flow.  Arch Physiol Biochem 2003; 111(4):319-321. 

-         Horvath G, Wanner A. Molecular targets for steroids in airway vascular smooth muscle. Arch Physiol           Biochem  2003; 111: 341-344

-         Mendes ES, Campos MA, Hurtado A, Wanner A.  Effect of montelukast and fluticasone mucosal            blood flow in asthma.  Am J Respir Crit Care Med 2004; 169:1131-1134.

-         Wanner A, Horvath G. Brieva JL, Kumar SD, Mendes, ES.  Non-genomic actions of glucocorticoids on           the  airway vaculature in asthma.  Proc Am Thorac Soc 2004; 1:235-238.

-         Horvath, G, Wanner, A.  Inhaled corticosteroids:  Effects on the airway vasculature in bronchial asthma.  Eur. J. Respir Dis 2006; 27: 172-87. 

-         Wanner A, Campos MA, Mendes E.  Airway blood flow reactivity in smokers.  Pulm Pharmacol Ther           2006

-         Wanner A, Mendes ES, Atkins ND.  A simplified non-invasive method to measure airway blood flow in           humans. J Appl Physiol 2006; 100: 1674-8.

-        Mendes ES, Campos MA, Wanner A.  Airway blood flow reactivity in healthy smokers and in ex-smokers with or without COPD.  Chest 2006; 129:893-8.

-         Kanwaldeep R,Mendes E, Wanner A. Acute Effect of Cigarette

          smoke and Nicotine on Airway Blood Flow and Airflow in Healthy Smokers.

          Lung 2006; 184:363-8

-         Horvath G, Schmid N, Fragoso M, Schmid A, Salathe M, Wanner A. Epithelial OCTN1/2

         organic cation/carnitin transporters ensure pH dependent drug absorption in the airway. 

         Am J Resp Cell Mol Biol 2007; 36:53-60

-        Horvath G, Vasas S, Wanner A. Inhaled corticosteroids reduce asthma-associated airway

    hyperperfusion through genomic and non-genomic mechanisms. Pulm Pharmacol Ther 

         2007; 20: 157-162 

-        Horvath G, Mendes ES, Schmid N, Schmid A, Conner GE, Salathe M, Wanner A. The

         effect of corticosteroids on the disposal of long-acting beta2-agonists by airway smooth

         muscle cells. J Allergy Clin Immunol 2007; 120: 1103-1109

-        Mendes ES, Campos MA, Wanner A. Acute effect of a glucocorticosteroid on beta-

         adrenergic airway and airway smooth muscle reactivity in patients with mild asthma. J 

         Allergy Clin Immunol 2008; 121:700-704

-        Mendes ES, Horvath G,  Monzon ME, Casalina-Matsuda1 M, Wanner A. Endothelial 

         dysfunction in healthy smokers. J Appl Physiol  2008; 105: 54-57

-        Morris NR, Ceridon ML, Beck KC, Strom NA, Schneider DA, Mendes ES, Wanner A,

         Johnson BD. Exercise-related chainge in airway blood flow in humans: relationship to 

         changes in cardiac output and ventilation. Resp Physiol Neurobiol 2008, 162:204-209

-        McCullagh A, Rosenthal M, Wanner A, Hurtado A, Padley S, Bush A.The bronchial

        circulation--worth a closer look: a review of the relationship between the bronchial

        vasculature and airway inflammation. Pediatr Pulmonol. 2010;45:1-13

-     . Wanner A, Mendes ES. Endothelial dysfunction in asthma and COPD. Amer J   

        Resp Crit Care Med 2010; 182:1344-51

-       Kirkpatrick B, Fleming LE, Bean JA, Nierenberg K, Backer LC, Cheng YS, Pierce R, Reich

         A, Naar J, Wanner A, Abraham W, Baden DG. Aerosolized Red Tide Toxin

        (Brevetoxins) and Asthma: Continued health effects after 1 hour beach exposure. Harmful  Algae

        2011; 10:138-143

-       Fleming , Barbara Kirkpatrick, Lorraine C. Backer, CathyJ.Walsh,Kate Nierenberg, John Naar,            Richard Pierce, Andrea J Bo Stuart Shalat, Porter Hoagland, Wendy Stephan,  Judy  Bean, Sharon         Watkins, Tainya Clarke, Margaret Byrne, Daniel G. Baden. Review of Florida Red Tide and         Human Health Effects.  Harmful  Algae 2011; 10: 224-233.

-      Bokhari S, Willens H, Lowery M, Wanner A, DeMarchena E. Orthodeoxia platypnia

        syndrome in a patient with lipomatous hypertrophy of inter-atrial septum due to chronic steroid         use. Chest 2011; 139:443-445

-       Horvath G, Mendes ES,  Schmid N, Schmid A,  Conner GE, Fregien N, Salathe M, Wanner A. Rapid

   nongenomic actions of inhaled corticosteroids on long- acting beta-2-agonist trafficking by human    airway epithelial and smooth muscle cells. Pulm  Pharmacol Ther 2011; 24: 654-659

-       Mendes ES, Rebolledo P, Wanner . Acute effects of Salmeterol and  Fluticasone alone       

         and in combination on airway blood flow in  subjects  with  asthma. Chest 2012;141:1184-1189

D.  Research Support

 

Ongoing Research Support

 

American Lung Association - Asthma Clinical Research Center (ACRC).  Principal Investigator.  7/1/99-6/30/14 ($2,250,000).

Acute effect of momethasone on beta-adrenergic airway and airway vascular relaxation in moderately severe asthmatics (Schering-Plow 2010; $ 55,000)

Carrier-mediated absorption and clearance of tiotropium in the airway (BI 2009; $110,000)

Effect of an Inhaled Glucocorticoid-long-acting beta adrenergic agonist on Endothelial Function in COPD (GSK 2010; $ 62,500)

Airway and pulmonary vascular endothelial function in healthy smokers: Effect of inhaled glucocorticosteroid treatment (:GSK, $ 125,000)

Effect of Roflumilast on Airway Blood Flow as an Expression of Airway Inflammation in COPD (Forest, $ 199,000)

Completed Research Support

 

NIH NIEHS 1PO1 ES 10594 ZES1- Project Title: “Effects of inhaled Florida red tide brevetoxins”  7/1/00-6/30/11.  Co-Investigator.

Florida RC1 grant 24248-The airway microbiome in COPD. 1/10/10-1/9/12. ($ 749,000). Principle investigator

NIH NIAID 1R18AI36908- School-Based Asthma Intervention Program, 9/1/94-08/31/03.  Principal Investigator.

NIH NIAID HL58086 - Alpha-Adrenergic Regulation of Airway Blood Flow, 4/1/98-3/31/03.  Principal Investigator. 

NIH 1R43HL59024- Automated System for Telephonic Management of Asthma (Asthma).  Co-principal Investigator.  04/1/99-03/31/01.

Acute effects of inhaled glucocorticoids on airway blood flow (GSK, 1999; $92,000).

Comparative vasoconstrictive actions of inhaled glucocorticoids (GSK, 2000; $49,000).

Racemic and R-albuterol on airway blood flow (Sepracor, 2000; $50,000). 

Effect of anti-inflammatory therapy on airway blood flow in asthma (Merck, 2003; $48,000).

 Airway blood flow reactivity in smokers with or without COPD.  (GSK, 2004; $52,000). 

Low-dose steroid pretreatment potentiates adrenergic airway and airway vascular responses in the airway (Sepracor, 2004; $50,000). 

Role of airway blood flow in exercise-induced asthma (Merck 2005; $59,000). 

Endothelial function in the airway of smokers (GSK 2005; $54,000). 

Effect of budesonide on formoterol disposal (AstraZeneca, 2005; $89,406). 

Interactive smooth muscle effects of salmeterol and fluticasone in the airway (GSK 2006; $ 50,625).

pH dependent drug transport mechanisms in the airway: implications for inhaled beta-2 adrenergic agonist therapy in asthma (AstraZeneca 2007; $ 166,703)

Effect of an inhaled glucocorticoid on endothelial function in cigarette smokers (GSK 2008; $73,831)

 

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