Sylvester Comprehensive Cancer Center

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Matthias A. Salathe, M.D.

General Information

Matthias A. Salathe, M.D.

Languages

  • English
  • German

Certifications

  • American Board of Internal Medicine
  • American Board of Internal Med-Pulmonary Disease
  • American Board of Internal Med-Critical Care Medicine

CV

Specialties

  • Internal Medicine
  • Pulmonary Disease - Internal Medicine
  • Critical Care Medicine-Internal Medicine

Roles

  • Chief, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine
  • Professor of Medicine and Molecular & Cellular Pharmacology
  • Vice Chair for Research

Clinical Interests

Cystic Fibrosis, Bronchiectasis, Non-tuberculous Mycobacterial Lung Disease, COPD

Research Interests

Airway epithelial cell biology, including pathobiology of chronic bronchitis and cystic fibrosis

The Salathe lab has experience studying airway diseases, in particular signaling in airway epithelial cells. Towards this end, it was instrumental in developing programs and microscope setups to measure ciliary beat frequency (CBF) and fluorescent signals (including Ca2+, pH, and FRET for PKA activation) simultaneously in the same single, live cell. The lab also adapted measurements for ASL volume determination. Together with collaborators, the lab has helped to establish a biorepository of airway epithelial cells from now >500 lungs (organ donors) used for air-liquid interface (ALI) cultures and airway samples from patients with airway diseases (including BAL, brushed cells, exhaled breath condensate, and blood for other analyses including cytokines and genetics). The lab initiated the development of lentivirus-based manipulation of airway epithelial cell proteins to measure cAMP by FRET (using fluorescently tagged PKA subunit expression in ciliated cells, driven by the ciliated cell specific foxj1 promoter) and to suppress proteins for analysis of their role in signal transduction (e.g., pannexin 1 by lentivirus-driven shRNA expression). Finally, the lab initiated measurements of ion transport activities in ALI cultures that recently revealed novel pathways of maintaining airway surface liquid (ASL) volume. We have also successfully built a clinical trial environment around the themes of cystic fibrosis and chronic bronchitis/COPD for PI initiated and pharmaceutically sponsored trials. The cystic fibrosis trial environment at the University of Miami achieved therapeutic development center status by the Cystic Fibrosis Foundation’s Therapeutic Development Network in 2009. 

Education

1987 M.D.
University of Basel School of Medicine
Residency
University of Basel; Jackson Memorial Hospital, University of Miami - Affiliated Medical Education Program
Fellowship
Jackson Memorial Hospital, University of Miami - Affiliated Medical Education Program

Publications

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