Sylvester Comprehensive Cancer Center

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Breelyn A. Wilky, M.D.

General Information

Breelyn A. Wilky, M.D.


  • English


  • American Board of Internal Medicine
  • American Board of Internal Med-Medical Oncology


  • Hematology/Oncology - Internal Medicine
  • Internal Medicine


  • Assistant Professor of Medical Oncology
  • Member, Molecular Oncology and Experimental Therapeutics (MOET) Program


Alpha Omega Alpha
Conquer Cancer Foundation/ASCO Young Investigator Award
Alpha Omega Alpha Postgraduate Award
Connie Caplan Medical Oncology Fellowship
Gold Humanism Honor Society


2009-2013 Fellowship
Johns Hopkins University
2006-2009 Internship and Residency
Johns Hopkins Hospital
2006 M.D. with Distinction in Research
University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School
2001 BS
Bates College


  • Kikuchi K, Hettmer S, Imran Aslam M, Michalek J, Laub W, Wilky B, Loeb D, Rubin B, Wagers A, Keller C. Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma. PLOS Genetics, 2014. 10(1):e1004107.
  • Trucco MM, Awad O, Wilky BA, Goldstein SD, Huang R, Walker RL, Shah P, Katuri V, Gul N, Zhu YJ, McCarthy EF, Paz-Priel I, Meltzer PS, Austin CP, Xia M, Loeb DM. A Novel Chordoma Xenograft Allows In Vivo Drug Testing and Reveals the Importance of NF-?B Signaling in Chordoma Biology. PLOS One, 2013. 8(11): e79950.
  • Wilky BA, Montgomery E, Guzzetta A, Ahuja N, Meyer C. Extrathoracic location and “borderline” histology are associated with recurrence of solitary fibrous tumors after surgical resection. Ann Surg Oncol 2013, 20(13) 4080-9.
  • Wilky BA, Meyer CF, Trent JC. Pazopanib in sarcomas: Expanding the PALETTE. Curr Opin Oncol. 2013, 25(4):373-8.
  • Scannell C, Pederson E, Mosher J, Krook M, Nicholls L, Wilky BA, Loeb D, Lawlor E. LGR5 is expressed by Ewing sarcoma and potentiates Wnt/ß-catenin signaling. Front Oncol. 2013, 3:81.
  • Thornton KA, Chen AR, Trucco MM, Shah P, Wilky BA, Gul N, Carrera-Haro MA, Ferreira MF, Shafique U, Powell JD, Meyer CF, Loeb DM. A dose finding study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcoma. Int J Cancer 2013, 133(4): 997-1005.
  • Wilky BA, Loeb DM. Beyond Palliation: Therapeutic Applications of 153Samarium-EDTMP. Clin Exp Pharmacol. 2013, 3:131.


My clinic consists of patients with sarcomas and other bone/soft tissue tumors, including gastrointestinal stromal tumors (GIST), desmoid fibromatosis, pigmented villonodular sclerosis (PVNS), chordomas, and solitary fibrous tumors.  I am also a clinical/translational researcher, with a focus on bringing new targeted therapies into early phase clinical trials for sarcoma patients

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