Sylvester Comprehensive Cancer Center

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John M. Goldberg, M.D.

General Information

John M. Goldberg, M.D.

Languages

  • English

Certifications

  • American Board of Pediatrics-Pediatric Hematology-Oncology

Specialties

  • Pediatrics
  • Pediatric Hematology-Oncology (Pediatrics)

Roles

  • Assistant Professor of Clinical Pediatrics
  • Director, Pediatric Oncology Early Phase Clinical Trials Program

Clinical Interests

Pediatric melanoma

Sarcoma

Pediatric renal cell carcinoma

Phase I clinical trials in pediatrics

Research Interests

My research interest is in translating laboratory discoveries into new therapies for children with relapsed cancer. We have specific expertise in using the immune system to attack cancer here at the Unversity of Miami, but in my role as Director of Phase I clinical trials for pediatric oncology, we are exploring any rational and promising strategies for pediatric cancer therapy. Please feel free to contact me for any potential collaborations on such clinical trials or if you are a patient or parent who would like to consider experimental treatments for a child with cancer.

Biography

My research focuses on the translation of laboratory discoveries into therapies for pediatric cancer. While at the Dana-Farber Cancer Institute, I spearheaded the implementation of a vaccine protocol in young people with tumors that share biology with melanoma. I was the co-Principle Investigator of protocol DFCI 05-115, under the mentorship of Dr. Steve Hodi of Cutaneous Oncology. This Phase I protocol accrued a dozen patients, 6 of whom are still alive after initiating the protocol in autumn, 2005. An adenoviral vector was used to transfer the gene for GM-CSF to an autologous tumor cell product that was given back to the patient to stimulate the immune system through paracrine secretion of GM-CSF. I have also helped start a multi-center Phase II study of a novel c-Met inhibitor for the same tumors treated in the vaccine protocol. Both the vaccine trial and the c-Met inhibitor trial were based on rationale described by colleagues in the laboratory.

In Boston, I worked in the laboratory of Dr. David E. Fisher in Pediatric Oncology at the Dana-Farber Cancer Institute. My clinical investigations involved collaboration with both Dr. Holcombe Grier and Dr. George Demetri. In Miami, I have been appointed to build a Phase I program for pediatric cancer within the Sylvester Comprehensive Cancer Center. Dr. Eli Gilboa has been appointed as my primary mentor, and has already begun directing me to new clinical trial ideas. My long-term goal is to develop a career as a translational researcher in the treatment of pediatric solid tumors, standing at the intersection of laboratory and clinical investigation, linking ideas from my laboratory based colleagues like c-Met inhibition directly to interested pharmaceutical companies. Clinically, I specialize in the treatment of children with sarcoma and melanoma, and have a position on the Rare Tumor Subcommittee of the Children’s Oncology Group, through which I can help to collect information about such patients.

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