Sylvester Comprehensive Cancer Center

Cancer Epidemiology & Prevention Program

Program Leader(s)

Description of the Program

This research program was developed from the Biobehavioral Oncology and Cancer Epidemiology Program, which was divided into two separate programs as new recruits provided added expertise in the cancer epidemiology area, warranting the creation of a separate program. The overall goal of the Cancer Epidemiology and Prevention (CEP) Program is to characterize cancer risk factors, develop effective interventions, and improve survival- particularly among underserved minority populations who experience disproportionately worse clinical outcomes.

To address this overarching goal, the program focuses on three inter-related program themes:

  • Etiology: Focuses on gene-gene and gene-environment exposures, infections, lifestyle, and socio-cultural determinants of cancer risk
  • Intervention: Focuses on smoking cessation and chemoprevention in high-risk populations
  • Diagnosis and Prognosis: Focuses on early detection and genetic prediction models of cancer progression and survival

The CEP program is a trans-disciplinary program involving members from the Departments of Epidemiology & Public Health, Otolaryngology, Biochemistry & Molecular Biology, Dermatology, Pediatrics, Surgery, Medicine and Psychology, representing population, laboratory, translational, and clinical investigators. Researchers in the CEP Program are charged with understanding and addressing the genetic, environmental, social and biological factors that contribute to disparities. These researchers are also working to clarify molecular and genetic mechanisms of cancer progression and prognosis. Particular strengths of the Program include Molecular Epidemiology, Community-based Participatory Research (CBPR), Tobacco Control, and Cancer Health Disparities research. Extensive interaction with community organizations and clinics for underserved populations with higher cancer mortality strengthens the CEP Program in conducting translational research to overcome cancer health disparities.

Over the next 5 years, the Program will build on existing strengths and focus on P01 and SPORE grant funding to expand intra- and inter-programmatic collaborations in: ( 1 ) Characterizing and overcoming the genetic, environmental, social and biological determinants of cancer health disparities; ( 2 ) Elucidating the molecular/genetic mechanisms of cancer risk/progression; ( 3 ) Validating predictive models in treatment response and survival; and ( 4 ) Improving cancer prevention, early detection, and clinical outcomes.

Goals of the Program

The scientific goals of the CEP Program are to:

1. Understand and address the genetic, environmental, social, and biological determinants of cancer disparities

2. Elucidate the molecular/genetic mechanisms of cancer risk and progression

3. Develop predictive models in treatment response

4. Improve cancer prevention, early detection, and clinical outcomes

Participants

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