Sylvester Comprehensive Cancer Center

Cancer Epigenetics Program

Program Leader(s)

Description of the Program

Mutations in genes involved in the epigenetic regulators of gene expression have now been found in a broad array of solid tumors and hematologic malignancies. These mutations affect not only DNA methylation and hydroxyl-methylation, but also the readers, writers and erasers of histone modifications. In fact, the discovery of mutations in sites of post-transcriptional modifications of histones in certain subtypes of cancer point to a key role for chromatin in oncogenesis. Additionally, the discovery of frequent mutations in DNMT3A in myeloid malignancies, and the finding that the TET2 and IDH mutations occur in similar cancers bring the role of these new mechanisms of transformation into focus.

The Cancer Epigenetics Research Program aims to build on their mechanistic knowledge of the pathogenesis of these malignancies and translate the important insights that are gained into novel, potentially more effective epigenetic-focused therapies of cancer. The program is taking advantage of their unique strengths and resources to develop a collaborative and interactive program that will create, distribute, and utilize novel cell based assays and mouse models of cancer. Our efforts will generate important bioinformatics and biochemical resources for the cancer community at-large. Importantly, the program will leverage their genomic and epigenetic infrastructure capabilities to develop personalized cancer medicine approaches for patients.

Goals of the Program

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