Amjad Farooq, Ph.D.
Associate Professor, Braman Family Breast Cancer Institute
Description of Research
Dr. Farooq's laboratory applies a diverse array of biophysical techniques to study macromolecular interactions at hydrodynamic, thermodynamic, kinetic and structural level in the context of key signaling circuitry pertinent to cell growth and differentiation, cell survival and motility, cell cycle regulation, apoptosis and cancer. His long-term goals are to apply the physicochemical principles emerging from his work to the rationale design of novel therapeutic approaches harboring greater efficacy coupled with low toxicity for the treatment of disease, with particular emphasis on combatting cancer.
- Demonstration that the binding of Grb2 adaptor to its downstream partners Sos1 and Gab1 to generate the Sos1-Grb2-Gab1 ternary signaling complex is under tight allosteric regulation, implying that the full understanding of cellular signal transduction pathways may require full understanding of allosteric phenomena encompassing protein behavior
- Discovery that the binding of ER&alpha and other nuclear receptors to DNA is coupled to proton uptake, implying that the nuclear receptors may act as pH sensors in orchestrating a multitude of physiological roles in health and cancer
Selected Cancer-Related Publications
- McDonald CB, Seldeen KL, Deegan BJ, Farooq A. SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner. Biochemistry 48:4074-85, 2009. Read more »