Bonnie Blomberg, Ph.D.
Associate Professor of Microbiology & Immunology
Description of Research
Dr.Blomberg's research focuses on the immune system and deficits that occur with age as well as the effects of CBSM (cognitive behavioral stress management) and relaxation therapy (RT) intervention in breast cancer patients on their immune system and inflammation. She is currently investigating the molecular and cellular pathways contributing to better conditions for immune response and survival in cancer patients.
- Compromised humoral immune response in aged individuals may be at least partially explained by molecular changes in transcription factors and enzymes which decrease the quality of the antibody molecule and B cell function
- Breast cancer patients show improved immune response and decreased inflammation after psychosocial intervention
Selected Cancer-Related Publications
- Swain SL, Blomberg BB. Immune senescence: new insights into defects but continued mystery of root causes. Curr Opin Immunol :,2013 Read more »
- Ratliff M, Alter S, Frasca D, Blomberg BB, Riley RL. In senescence,age-associated B cells secrete TNF? and inhibit survival of B-cell precursors*. Aging Cell 12:303-11,2013 Read more »
- Frasca D, Romero M, Diaz A, Alter-Wolf S, Ratliff M, Landin AM, Riley RL, Blomberg BB. A Molecular Mechanism for TNF-?-Mediated Downregulation of B Cell Responses. J Immunol 188:279-86,2012 Read more »
- Landin AM, Frasca D, Harrison P, Scallan M, Riley RL, Blomberg BB. E47 retroviral rescue of intrinsic B-cell defects in senescent mice. Aging Cell 10:327-37,2011 [JIF 7.148] Read more »
Collaborating in the Multidisciplinary Research Program(s):