Jean L. Wright, M.D.
Assistant Professor of Radiation Oncology
Description of Research
Dr. Wright’s primary interest is in breast cancer research. She is focusing her efforts on the study of the management of locally advanced breast cancer and devotes the majority of her clinical time to management of breast cancer patients at Jackson Memorial Hospital and Sylvester Comprehensive Cancer Center- both of which serve a large volume of patients with locally advanced disease. She currently works as a co-investigator in the newly funded study (PI: Hu, CA135288) entitled “Impact of Genomics on Disparities in Breast Cancer Radiosensitivity”, which examines genomics and radiosensitivity in breast cancer patients who receive a lumpectomy followed by radiotherapy. She has also recently obtained funding to expand this research to the population of patients with locally advanced breast cancer receiving radiation after mastectomy, “Molecular Genetics of Radiation-Induced Skin Toxicities in a Tri-Racial/Ethnic Post-Mastectomy Breast Cancer Cohort” (PI: Wright, 1BN08-3418). The outcome of this research will allow us to better understand genetic predisposition to more severe radiation skin reaction, and to understand racial and ethnic differences in radiation reaction. In addition, she has worked to develop a retrospective database of patients who have been treated with post-mastectomy radiation; and has published 5 abstracts based on this database of 600 patients treated over a 10-year span. Finally, she is involved in the development of a new prospective database for the radiation oncology department, for which all breast cancer patients treated in the department are being approached for consent and participation. She is working with her colleague Dr. Cristiane Takita to develop treatment algorithms that can then be studied. In addition, Dr. Wright performs research on lung malignancies, and has designed and written a protocol entitled “A Phase I Study Evaluating the Safety of Lattice Extreme Ablative Dose (LEAD) Radiotherapy Followed by Standard-Dose Chemoradiation for Bulky Stage III Non-Small Cell Lung Cancer”. This study is designed to assess the safety and toxicity of a novel radiation approach to non-small cell lung cancer, utilizing a single fraction of high dose radiation using a 3-dimensional spatially fractionated technique, followed by standard concurrent chemotherapy and radiation.
- The finding that implant-based reconstruction can be safely integrated into post-mastectomy radiation treatment algorithms with acceptably low recurrence rates
- The finding that higher radiation dose is associated with improved loco-regional control in locally advanced breast cancer patients receiving post-mastectomy radiation
- The finding that radiation to the supraclavicular lymph nodes may be omitted in selected patients who have negative lymph nodes after neoadjuvant chemotherapy
Selected Cancer-Related Publications
- Wright JL, Patil SM, Temple LK, Minsky BD, Saltz LB, Goodman KA. Squamous Cell Carcinoma of the Anal Canal: Patterns and Predictors of Failure and Implications for Intensity-Modulated Radiation Treatment Planning. Int J Radiat Oncol Biol Phys, 2010 [Epub ahead of print] Read more »