Sylvester Comprehensive Cancer Center

Keith A. Webster, Ph.D.

Keith A. Webster, Ph.D.

Associate Professor of Molecular & Cellular Pharmacology

Description of Research

Molecular mechanisms of hypoxia/ischemia-regulated gene expression. Gene therapy with "Intelligent Gene" delivery techniques. In addition to unraveling the consequences of hypoxia in different tissues, we have used the information to design strategies to treat and reverse both the effects of hypoxia and the hypoxia itself. We have achieved this by developing specific genes and specific gene delivery techniques such that we can efficiently and safely deliver protective genes to the areas affected by hypoxia. We are especially interested in delivering therapeutic genes to patients with heart disease and cancer patients with solid tumors. The gene therapy technique that we have developed to do this is called "Intelligent gene" delivery.

Highlights

  • Developed gene therapy technique called "Intelligent gene" delivery to efficiently and safely deliver protective genes to the areas affected by hypoxia and therapeutic genes to patients with heart disease and cancer patients with solid tumors.

Selected Cancer-Related Publications

  • Tan Y, Li Y, Xiao J, Shao H, Ding C, Arteel GE, Webster KA, Yan J, Yu H, Cai L, Li X. A novel CXCR4 antagonist derived from human SDF-1beta enhances angiogenesis in ischaemic mice. Cardiovasc Res 82:513-21, 2009. Read more »
  • Wu H, Jin Y, Arias J, Bassuk J, Uryash A, Kurlansky P, Webster K, Adams JA. In vivo upregulation of nitric oxide synthases in healthy rats. Nitric Oxide 21:63-8, 2009. Read more »

Programs

Collaborating in the Multidisciplinary Research Program(s):

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