Sylvester Comprehensive Cancer Center

Lynn G. Feun, M.D.

Lynn G. Feun, M.D.

Professor of Medicine

Description of Research

Dr. Feun’s research laboratory focuses on melanoma, hepatomas, brain gliomas and regional therapy as well as novel agents in phase I-II trials in melanoma and cancers of the hepatobiliary system.


  • Participated in Phase I and Phase II trials of arginine deiminase in melanoma. The results were presented at the American Society of Clinical Oncology. This led to an R01 grant.
  • In collaboration with Dr. Savaraj at the University of Miami, and Dr. Kuo at MD Anderson Hospital, obtained an R01 grant to study mechanisms of resistance to arginine deiminase therapy in melanoma, and possible methods to overcome this resistance.
  • Dr Feun is currently investigating a novel hormonal therapy for patients with unresectable hepatocellular carcinoma (liver cancer).

Selected Cancer-Related Publications

  • Long Y, Tsai WB, Wangpaichitr M, Tsukamoto T, Savarah N, Feun LG, Kuo MT. Arginine Deiminase Resistance in Melanoma Cells Is Associated with Metabolic Reprogramming,Glucose Dependence and Glutamine Addiction. Mol Cancer Ther :,2013 Read more »
  • Yoon JK, Frankel AE, Feun LG, Ekmekcioglu S, Kim KB. Arginine deprivation therapy for malignant melanoma. Clin Pharmacol 5:11-9,2013 Read more »
  • Tsai WB, Aiba I, Long Y, Lin HK, Feun L, Savaraj N, Kuo MT. Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase,Leading to Arginine Deiminase Resistance in Melanoma Cells. Cancer Res 72:2622-33,2012 Read more »
  • You M, Savaraj N, Kuo MT, Wangpaichitr M, Varona-Santos J, Wu C, Nguyen DM, Feun L. TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Mol Cell Biochem :,2012 Read more »
  • Feun LG, Marini A, Walker G, Elgart G, Moffat F, Rodgers SE, Wu CJ, You M, Wangpaichitr M, Kuo MT, Sisson W, Jungbluth AA, Bomalaski J, Savaraj N. Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase. Br J Cancer 106:1481-5,2012 Read more »
  • Wangpaichitr M, Sullivan EJ, Theodoropoulos G, Wu C, You M, Feun LG, Lampidis TJ, Kuo MT, Savaraj N. The Relationship of Thioredoxin-1 and Cisplatin Resistance: Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells. Mol Cancer Ther 11:604-15,2012 Read more »
  • Wykoff CC, Murray TG, Markoe AM, Feun LG, Schefler AC, Gayer S. Preoperative evaluation for patients with choroidal/ciliary body melanomas: what is necessary? Am J Ophthalmol 151:921-4,2011 Read more »
  • Sasine JP, Feun LG. Topoisomerase I Inhibitors in the Treatment of Primary CNS Malignancies: An Update on Recent Trends. Anticancer Agents Med Chem :,2011 Read more »
  • Sasine JP, Savaraj N, Feun LG. Topoisomerase I Inhibitors in the Treatment of Primary CNS Malignancies: An Update on Recent Trends. Anticancer Agents Med Chem 10:683-696,2010 Read more »
  • Kuo MT, Savaraj N, Feun LG. Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Oncotarget 1:246-251,2010 Read more »
  • Wu J, Henderson C, Feun L, Van Veldhuizen P, Gold P, Zheng H, Ryan T, Blaszkowsky LS, Chen H, Costa M, Rosenzweig B, Nierodzik M, Hochster H, Muggia F, Abbadessa G, Lewis J, Zhu AX. Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma. Invest New Drugs 28:670-6,2010 Read more »

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