Marc Lippman, M.D.
Professor of Medicine
Description of Research
Dr. Lippman has attempted to bridge the gap between basic tumor biology and clinical application in the field of breast cancer. His work established the critical role of growth factors in human breast cancer, and in an extensive series of studies, has characterized and purified these factors and designed antitumor therapies based on these insights. He has received the Clinical Investigator Prize of the American Federation for Clinical Research, the Rosenthal Award of the American Association for Cancer Research, the American Cancer Society Lectureship awarded by the American Society for Clinical Oncology, the Astwood Prize of the Endocrine Society, and the Brinker International Prize for Basic Research in Breast Cancer. He has authored over 500 publications, and one of the standard texts on breast cancer, and has successfully pursued clinical trials for every stage of breast cancer patients, with most of these studies reflecting his special joining of clinical with basic science.
His current research is focused on host contributions to malignant progression of breast cancer. His lab has developed robust models of human breast cancer which metastasize widely in model systems. Using parallel gene array strategies changes in gene expression that occur in breast cancers themselves can be separated from induced changes in host stroma. This has led to the discovery of a signature associated with metastatic disease which suggests that infiltration of a specific cohort of leukocytes [myelo-derived suppressor cells] is both associated and required for metastatic behavior. The signals which induce recruitment of these cells overlap with those seen ion depression and central obesity linking critical host changes with malignant progression. Multiple studies are underway targeting these pathways.
- Established the critical role of growth factors in human breast cancer, and in an extensive series of studies, has characterized and purified these factors and designed antitumor therapies
- Defined a critical role for tumor induced changes in the host which augment malignant progression of breast cancer.
Selected Cancer-Related Publications
- Iorns E, Hnatyszyn HJ, Seo P, Clarke J, Ward T, Lippman M. The Role of SATB1 in Breast Cancer Pathogenesis. J Natl Cancer Inst 102:1284-96, 2010 Read more »
- Sikora MJ, Cordero KE, Larios JM, Johnson MD, Lippman ME, Rae JM. The androgen metabolite 5alpha-androstane-3beta, 17beta-diol (3betaAdiol) induces breast cancer growth via estrogen receptor: implications for aromatase inhibitor resistance. Breast Cancer Res Treat 115:289-96, 2009. Read more »
Collaborating in the Multidisciplinary Research Program(s):