Sylvester Comprehensive Cancer Center

Mark S. Soloway, M.D.

Mark S. Soloway, M.D.

Professor of Urology

Description of Research

Dr. Soloway has a large database of over 225 men with prostate cancer (PC) that have been managed with an active surveillance (AS) strategy. He feels that all men with PC do not require active treatment at the time of diagnosis. For those men who meet certain criteria, i.e. very small volume low grade PC, initial therapy with potential side effects may be over-treatment. The risk of progression and death from PC in these men is very low. He has one of the largest data sets regarding initial AS in the country. As reported in 2 publications only 15% of these men have been treated and none has had their cancer spread beyond the prostate. None have died of PC. The mean follow up is over 4 yrs and some have been followed over 10 years.

Dr. Soloway was the chair of an International Committee whose task was to provide guidelines for bladder cancer (BC). The results and recommendations were reported in 2004. He has been asked to again Chair an international committee of BC experts to report in 2011 on a current set of recommendations on all aspects of this cancer.

Dr. Soloway has a database of over 2000 men who have had a total prostatectomy performed by him. The evaluation, surgery, and pathology review are thus uniform and the data on follow up provide an excellent insight into the outcome of surgically treated PC. This data has been the subject of many publications in peer reviewed journals such as European Urology, British Journal of Urology, Urology, Journal of Urology, Canadian Journal of Urology, and the Brazilian Journal of Urology.

Dr. Soloway has also published extensively about the management of bladder cancer. He has discussed the role of intravesical therapy in the management of Ta and T1 bladder cancer to decrease the recurrence rate. Working closely with Dr. Gaetano Ciancio, Dr. Soloway has been a co-author on numerous papers detailing the surgical technique developed by these two surgeons to incorporate liver transplant techniques for the removal of large renal cancers. This is particularly germane for the tumors that grow into the inferior vena cava. These cases provide a major technical challenge. These surgeons have successfully operated on over 100 men and women with these life threatening renal cancers. Their surgical techniques have been adopted by many surgeons throughout the world. Last year they made a movie of their technique and this was published and distributed by European Urology.

Highlights

Selected Cancer-Related Publications

  • Soloway MS. Legends of Urology. Can J Urol 16:4447-4449, 2009. Read more »
  • Eggener SE, Mueller A, Berglund RK, Ayyathurai R, Soloway C, Soloway MS, Abouassaly R, Klein EA, Jones SJ, Zappavigna C, Goldenberg L, Scardino PT, Eastham JA, Guillonneau B. A multi-institutional evaluation of active surveillance for low risk prostate cancer. J Urol 181:1635-41; discussion 1641, 2009. Read more »
  • Ciancio G, Soloway M, Livingstone AS. The increasing use of liver transplantation surgical techniques in the management of renal and nonrenal cancer with or without inferior vena cava tumor thrombus. World J Surg 33:1328-9, 2009. Read more »
  • Soloway MS. Editorial comment. With many other neoplasms,bladder cancer is heterogeneous. Urology 73:1311, 2009. Read more »
  • Soloway M. Incomplete prostatectomy for cancer. Curr Urol Rep 10:1-3, 2009. Read more »
  • Sachedina N, De Los Santos R, Manoharan M, Soloway MS. Total prostatectomy and lymph node dissection may be done safely without pelvic drainage: an extended experience of over 600 cases. Can J Urol 16:4721-5, 2009. Read more »
  • Shirodkar SP, Kishore T, Soloway MS. The risk and prophylactic management of bladder cancer after various forms of radiotherapy. Curr Opin Urol 19:500-503,2009. Read more »
  • Gomez CS, Gomez P, Knapp J, Jorda M, Soloway MS, Lokeshwar VB. Hyaluronic Acid and HYAL-1 in Prostate Biopsy Specimens: Predictors of Biochemical Recurrence. J Urol 182:1350-6,2009. Read more »
  • Shirodkar SP, Ciancio G, Soloway MS. Vascular Stapling of the Inferior Vena Cava: Further Refinement of Techniques for the Excision of Extensive Renal Cell Carcinoma With Unresectable Vena-caval Involvement. Urology 74:846-50,2009. Read more »

Programs

Collaborating in the Multidisciplinary Research Program(s):

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