Sylvester Comprehensive Cancer Center

Richard J. Cote, M.D.

Richard J. Cote, M.D.

Professor and Chair, Department of Pathology

Description of Research

The following are Dr. Cote’s major areas of research interest, and research in progress:

  • Detection and characterization of micrometastases in patients with epithelial tumors, including national and international clinical trials in breast cancer and lung cancer
  • Molecular mechanisms of tumor progression and response to therapy
  • Molecular mechanisms of racial/ethnic variation in prostate cancer risk
  • p53 targeted therapy trial in bladder cancer, national and international clinical trial studies
  • Development of novel biosensors for protein analysis
  • Development of nanotechnology platforms for cancer applications
  • Integrated microdevice to capture, detect and characterize circulating tumor cells

Highlights

  • Establishment of BioNIUM with funding support from Dr. John T. Macdonald Foundation and matching support from University of Miami
  • An inventor of the nanosensor and circulating tumor cell capture technology platforms
  • Principal Investigator for 32 federal and state-funded research grants, with $25 Million in funding
  • An author of over 200 peer-reviewed publications
  • Six awarded and three in-process patent applications
  • Participation in multi-institutional clinical trials in prostate, breast, lung and bladder cancers for detection and characterization of micrometastases in patients
  • p53 targeted therapy trial in bladder cancer, national and international clinical trial studies
  • Demonstration of sensitive development of nanotechnology-based platforms for applications in cancer and virology
  • Development of an integrated microdevice to capture and detect circulating tumor cells




    • Selected Cancer-Related Publications

      • Youseff RF, Mitra AP, Bartsch G Jr, Jones PA, Skinner DG, Cote RJ. Molecular Targets and targeted therapies in bladder cancer management. World J Urol 27:9-20, 2009. Read more »
      • Balic M, Pichler M, Strutz J, Heitzer E, Ausch C, Samonigg H, Cote RJ, Dandachi N. High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis. J Mol Diagn 11:102-8, 2009. Read more »
      • Shariat SF, Lotan Y, Karakiewicz PI, Ashfaq R, Isbarn H, Fradet Y, Bastian PJ, Nielsen ME, Capitanio U, Jeldres C, Montorsi F, Müller SC, Karam JA, Heukamp LC, Netto G, Lerner SP, Sagalowsky AI, Cote RJ. p53 Predictive value for pT1-2 N0 disease at radical cystectomy. J Urol 182:907-13,2009. Read more »
      • Mitra AP, Pagliarulo V, Yang D, Waldman FM, Datar RH, Skinner DG, Groshen S, Cote RJ. Generation of a concise gene panel for outcome prediction in urinary bladder cancer. J Clin Oncol 27:3929-37, 2009. Read more »

      Programs

      Leader of the Multidisciplinary Research Program: Genitourinary Malignancies Program

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