Ram H. Datar, Ph.D.
Associate Professor of Pathology and Biochemistry & Molecular Biology
Description of Research
Dr. Datar's areas of research focus include cancer molecular pathology and biomedical nanotechnology. Specifically, he has been involved in various aspects of detection and molecular characterization of occult metastases in cancers of prostate, bladder, breast and lung.
Dr. Datar has also been involved for many years in the development and application of micro- and nanoscale devices for biomedical diagnostic applications. His goal is to employ microfabrication and development of microfluidic devices to further novel technology development, including biosensors and molecular methods to analyze expression profiles of cancers.
- Principal Investigator in an NIJ forensic science award, Co-PI in an NIH R21/R33 IMAT Award and a Co-investigator in approximately 9 NIH, DoD and other State Awards
- Published over 60 original papers
- A reviewer for a number of international biomedical journals; and an editor for Current Issues in Molecular Biology, Caister Academic Press, UK.
- Serves as a member on NIH Study Sections and NSF Special Panels.
- Played a pivotal role in the development of the microfilter device for capture and characterization of the circulating tumor cells (CTC) and is among the inventors of the technology.
- Other achievements include contribution to the development of p53 GeneChip assays (where he served as Consultant for Roche Molecular Diagnostics) and q-RT-PCR marker assays for breast cancer (Consultant to Abbott Inc.) and expertise in global genomic DNA amplification and telomerase assays for molecular and functional characterization of tumors.
- Four awarded and three in-process patent applications
- Jointly with Dr. Richard Cote, Dr. Datar has mentored 6 Clinical Fellows, 6 doctoral students and 3 Masters students at University of Southern California
- Currently mentoring one graduate student and co-mentoring two graduate students with Dr. Cote
Selected Cancer-Related Publications
- Mitra AP, Pagliarulo V, Yang D, Waldman FM, Datar RH, Skinner DG, Groshen S, Cote RJ. Generation of a concise gene panel for outcome prediction in urinary bladder cancer. J Clin Oncol 27:3929-37, 2009. Read more »
Collaborating in the Multidisciplinary Research Program(s):