Sharon Elliot, Ph.D.
Associate Professor of Surgery
Description of Research
Endocrinology/Signal Transduction: Dr. Elliot's current research focuses on oxidant stress-induced changes in ER expression and function. This is applicable to many cancers including breast and thyroid. Dr. Elliot is interested in the influence of estrogens on retrograde signaling between the mitochondria and nucleus and how this may promote cancer invasiveness.
- Received the 2011 Endocrine Society Summer Research Fellowships (Maurice Raben Sponsored Fellowship Award) for thyroid cancer
- Exploring how ROS-induced mitochondrial signaling may be involved in cancer progression and metastasis
Selected Cancer-Related Publications
- Chen Y, Guggisberg N, Jorda M, Gonzalez-Angulo A, Hennessy B, Mills GB, Tan CK, Slingerland JM. Combined Src and Aromatase Inhibition Impairs Human Breast Cancer Growth In vivo and Bypass Pathways Are Activated in AZD0530-Resistant Tumors. Clin Cancer Res 15:3396-405, 2009. Read more »
- Catanuto P, Doublier S, Lupia E, Fornoni A, Berho M, Karl M, Striker GE, Xia X, Elliot S. 17 beta-estradiol and tamoxifen upregulate estrogen receptor beta expression and control podocyte signaling pathways in a model of type 2 diabetes. Kidney Int 75:1194-201, 2009. Read more »
- Kassira N, Glassberg MK, Jones C, Pincus DJ, Elliot SJ, Fritz JR, Karl M, Thaller S. Estrogen deficiency and tobacco smoke exposure promote matrix metalloproteinase-13 activation in skin of aging B6 mice. Ann Plast Surg 63:318-22,2009. Read more »