Sylvester Comprehensive Cancer Center

Steven E. Lipshultz, M.D.

Steven E. Lipshultz, M.D.

Professor of Pediatrics

Description of Research

Dr. Lipshultz’s research interest focuses on how to prevent cardiomyopathy and heart failure in children and young adults. He developed the National Heart, Lung, and Blood Institute (NHLBI) Pediatric Cardiomyopathy Registry (PCMR) to better understand the genetic and metabolic cardiomyopathies, developed the NHLBI P2C2 HIV study to better understand infectious and inflammatory cardiomyopathies, and created the NCI DFCI childhood leukemia and NCI COG childhood cancer survivor cohorts to better understand toxic cardiomyopathies from anthracycline chemotherapy and mediastinal irradiation. Further understanding of clinical phenotypes, human syndrome delineation, epidemiology, and natural history of these pediatric diseases has resulted from these cohorts.

Highlights

  • Developed the National Heart, Lung, and Blood Institute (NHLBI) Pediatric Cardiomyopathy Registry (PCMR) to better understand the genetic and metabolic cardiomyopathies
  • Developed the NHLBI P2C2 HIV study to better understand infectious and inflammatory cardiomyopathies
  • Created the NCI DFCI childhood leukemia and NCI COG childhood cancer survivor cohorts to better understand toxic cardiomyopathies from anthracycline chemotherapy and mediastinal irradiation

Selected Cancer-Related Publications

  • Landy DC, Lipsitz SR, Kurtz JM, Hinkle AS, Constine LS, Adams MJ, Lipshultz SE, Miller TL. Dietary quality,caloric intake,and adiposity of childhood cancer survivors and their siblings: an analysis from the cardiac risk factors in childhood cancer survivors study. Nutr Cancer 65:547-55,2013 Read more »
  • Lipshultz SE, Adams MJ, Colan SD, Constine LS, Herman EH, Hsu DT, Hudson MM, Kremer LC, Landy DC, Miller TL, Oeffinger KC, Rosenthal DN, Sable CA, Sallan SE, Singh GK, Steinberger J, Cochran TR, Wilkinson JD. Long-term Cardiovascular Toxicity in Children,Adolescents,and Young Adults Who Receive Cancer Therapy: Pathophysiology,Course,Monitoring,Management,Prevention,and Research Directions: A Scientific Statement From the American Heart Association. Circulation 128:1927-95,2013 Read more »
  • Lipshultz SE, Lipsitz SR, Kutok JL, Miller TL, Colan SD, Neuberg DS, Stevenson KE, Fleming MD, Sallan SE, Franco VI, Henkel JM, Asselin BL, Athale UH, Clavell LA, Michon B, Laverdiere C, Larsen E, Kelly KM, Silverman LB. Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia. Cancer :,2013 Read more »
  • Lipshultz SE, Franco VI, Cochran TR. Cardiotoxicity in childhood cancer survivors: A problem with long-term consequences in need of early detection and prevention. Pediatr Blood Cancer :,2013 Read more »
  • Little MP, Zablotska LB, Lipshultz SE. Ischemic heart disease after breast cancer radiotherapy. N Engl J Med 368:2523-4,2013 Read more »
  • Vrooman LM, Stevenson KE, Supko JG, O'Brien J, Dahlberg SE, Asselin BL, Athale UH, Clavell LA, Kelly KM, Kutok JL, Laverdière C, Lipshultz SE, Michon B, Schorin M, Relling MV, Cohen HJ, Neuberg DS, Sallan SE, Silverman LB. Postinduction Dexamethasone and Individualized Dosing of Escherichia Coli L-Asparaginase Each Improve Outcome of Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia: Results From a Randomized Study--Dana-Farber Cancer Institute ALL Consortium Protocol 00-01. J Clin Oncol 31:1202-10,2013 Read more »
  • Zerra P, Cochran TR, Franco VI, Lipshultz SE. An expert opinion on pharmacologic approaches to reducing the cardiotoxicity of childhood acute lymphoblastic leukemia therapies. Expert Opin Pharmacother :,2013 Read more »
  • Miller AM, Lopez-Mitnik G, Somarriba G, Lipsitz SR, Hinkle AS, Constine LS, Lipshultz SE, Miller TL. Exercise capacity in long-term survivors of pediatric cancer: An analysis from the cardiac risk factors in childhood cancer survivors study. Pediatr Blood Cancer :,2012 Read more »
  • Lipshultz SE, Landy DC, Lopez-Mitnik G, Lipsitz SR, Hinkle AS, Constine LS, French CA, Rovitelli AM, Proukou C, Adams MJ, Miller TL. Cardiovascular status of childhood cancer survivors exposed and unexposed to cardiotoxic therapy. J Clin Oncol 30:1050-7,2012 Read more »
  • Lipshultz SE, Miller TL, Lipsitz SR, Neuberg DS, Dahlberg SE, Colan SD, Silverman LB, Henkel JM, Franco VI, Cushman LL, Asselin BL, Clavell LA, Athale U, Michon B, Laverdière C, Schorin MA, Larsen E, Usmani N, Sallan SE. Continuous Versus Bolus Infusion of Doxorubicin in Children With ALL: Long-term Cardiac Outcomes. Pediatrics 130:1003-1011,2012 Read more »
  • Lipshultz SE, Miller TL, Scully RE, Lipsitz SR, Rifai N, Silverman LB, Colan SD, Neuberg DS, Dahlberg SE, Henkel JM, Asselin BL, Athale UH, Clavell LA, Laverdière C, Michon B, Schorin MA, Sallan SE. Changes in cardiac biomarkers during Doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes. J Clin Oncol 30:1042-9,2012 Read more »
  • Lipshultz SE, Cochran TR, Wilkinson JD. Screening for long-term cardiac status during cancer treatment. Circ Cardiovasc Imaging 5:555-8,2012 Read more »
  • Landy DC, Miller TL, Lipsitz SR, Lopez-Mitnik G, Hinkle AS, Constine LS, Adams MJ, Lipshultz SE. Cranial Irradiation as an Additional Risk Factor for Anthracycline Cardiotoxicity in Childhood Cancer Survivors: An Analysis from the Cardiac Risk Factors in Childhood Cancer Survivors Study. Pediatr Cardiol :,2012 Read more »
  • Landy DC, Miller TL, Lopez-Mitnik G, Lipsitz SR, Hinkle AS, Constine LS, French CA, Rovitelli AM, Adams MJ, Lipshultz SE. Aggregating traditional cardiovascular disease risk factors to assess the cardiometabolic health of childhood cancer survivors: An analysis from the Cardiac Risk Factors in Childhood Cancer Survivors Study. Am Heart J 163:295-301.e2,2012 Read more »
  • Ebb D, Meyers P, Grier H, Bernstein M, Gorlick R, Lipshultz SE, Krailo M, Devidas M, Barkauskas DA, Siegal GP, Ferguson WS, Letson GD, Marcus K, Goorin A, Beardsley P, Marina N. Phase II Trial of Trastuzumab in Combination With Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma With Human Epidermal Growth Factor Receptor 2 Overexpression: A Report From the Children's Oncology Group. J Clin Oncol 30:2545-51,2012 Read more »
  • Goldberg JM, Scully RE, Sallan SE, Lipshultz SE. Cardiac failure 30 years after treatment containing anthracycline for childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 34:395-7,2012 Read more »
  • Harake D, Franco VI, Henkel JM, Miller TL, Lipshultz SE. Cardiotoxicity in childhood cancer survivors: strategies for prevention and management. Future Cardiol 8:647-70,2012 Read more »
  • Jean-Pierre P, Winters PC, Ahles TA, Antoni M, Armstrong FD, Penedo F, Lipshultz SE, Miller TL, Fiscella K. Prevalence of self-reported memory problems in adult cancer survivors: a national cross-sectional study. J Oncol Pract 8:30-4,2012 Read more »
  • Franco VI, Henkel JM, Miller TL, Lipshultz SE. Cardiovascular effects in childhood cancer survivors treated with anthracyclines. Cardiol Res Pract 2011:134679,2011 Read more »
  • Trachtenberg BH, Landy DC, Franco VI, Henkel JM, Pearson EJ, Miller TL, Lipshultz SE. Anthracycline-associated cardiotoxicity in survivors of childhood cancer. Pediatr Cardiol 32:342-53,2011 Read more »
  • Vrooman LM, Neuberg DS, Stevenson KE, Asselin BL, Athale UH, Clavell L, Cole PD, Kelly KM, Larsen EC, Laverdière C, Michon B, Schorin M, Schwartz CL, Cohen HJ, Lipshultz SE, Silverman LB, Sallan SE. The low incidence of secondary acute myelogenous leukaemia in children and adolescents treated with dexrazoxane for acute lymphoblastic leukaemia: A report from the Dana-Farber Cancer Institute ALL Consortium. Eur J Cancer 47:1373-9,2011 Read more »
  • Adams MJ, Shore RE, Dozier A, Lipshultz SE, Schwartz RG, Constine LS, Pearson TA, Stovall M, Thevenet-Morrison K, Fisher SG. Thyroid Cancer Risk 40+ Years after Irradiation for an Enlarged Thymus: An Update of the Hempelmann Cohort. Radiat Res :,2010 Read more »
  • Lipshultz SE, Scully RE, Lipsitz SR, Sallan SE, Silverman LB, Miller TL, Barry EV, Asselin BL, Athale U, Clavell LA, Larsen E, Moghrabi A, Samson Y, Michon B, Schorin MA, Cohen HJ, Neuberg DS, Orav EJ, Colan SD. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective,randomised,multicentre trial. Lancet Oncol 11:950-61,2010 [JIF 14.470] Read more »
  • Miller TL, Lipsitz SR, Lopez-Mitnik G, Hinkle AS, Constine LS, Adams MJ, French C, Proukou C, Rovitelli A, Lipshultz SE. Characteristics and determinants of adiposity in pediatric cancer survivors. Cancer Epidemiol Biomarkers Prev 19:2013-22,2010 Read more »

Programs

Collaborating in the Multidisciplinary Research Program(s):

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